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Fibronectin glomerulopathy

2 OMIM references -
1 associated gene
10 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

6 OMIM references -
6 associated genes
3 signs/symptoms

Fibronectin glomerulopathy

Neuroblastoma

FN1	(UniProt - OMIM)		ALK	(UniProt - OMIM)
			HACE1	(UniProt - OMIM)
			LIN28B	(UniProt - OMIM)
			MYCN	(UniProt - OMIM)
			PHOX2B	(UniProt - OMIM)
			TOP2A	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	FN1	(0.63)	TOP2A

Citations in the biomedical literature:

Fibronectin glomerulopathy		Neuroblastoma
	Synonym(s): - GFND - Glomerulopathy with fibronectin deposits		Synonym(s): - Neural crest tumor - Sympathoblastoma

	Classification (Orphanet): - Rare genetic disease - Rare renal disease		Classification (Orphanet): - Rare neurologic disease - Rare oncologic disease

	Classification (ICD10): - Diseases of the genitourinary system -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: childhood Average age of death: child / adolescent Type of inheritance: sporadic

	External references: 2 OMIM references - No MeSH references		External references: 6 OMIM references - 2 MeSH references: C536408 / D009447


COMMON SIGNS	- Autosomal dominant inheritance

Fibronectin glomerulopathy		Neuroblastoma
	Very frequent - Chronic arterial hypertension - Edema of the legs / lower limbs - Functional anomalies of the kidney and the urinary tract - Hematuria / microhematuria - Nephrotic syndrome - Proteinuria - Renal failure - Renal glomerular defect / glomerulopathy Occasional - Intracranial / cerebral / meningeal hemorrhage		Very frequent - Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer - Organic acid metabolism anomalies